Jonny Karunia Fajar, Teuku Heriansyah, Mohammad Saifur Rohman
Objective: To investigate the no reflow risk factors after percutaneous coronary intervention in ST elevation myocardial infarction patients. Method: Sample size, mean ± standard deviation (SD) or frequencies (percent) of normal and no reflow groups were extracted from each study. Results: Of 27 retrospective and prospective studies, we found that increasing risks of no reflow were associated with advanced age, male, family history of coronary artery disease, smoking, diabetes mellitus, hypertension, delayed reperfusion, killip class ≥2, elevated blood glucose, increased creatinine, elevated creatine kinase (CK), higher heart rate, decreased left ventricular ejection fraction (LVEF), collateral flow ≤1, longer lesion length, multivessel disease, reference luminal diameter, initial thrombolysis in myocardial infarction (TIMI) flow, and high thrombus burden. Moreover, initial TIMI flow ≤1 and high thrombus burden had the greater impact on no reflow (OR95%CI = 3.83 [2.77–5.29], p < 0.0001 and 3.69 [2.39–5.68], p < 0.0001, respectively). Conclusion: Our meta-analysis reveals that initial TIMI flow ≤1 and high thrombus burden are the most impacted no reflow risk factors. © 2018
Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, 23111, Indonesia; Department of Emergency, Aisyiyah Hospital, Malang, 65117, East Java, Indonesia; Department of Cardiology and Vascular Medicine, School of Medicine, Syiah Kuala University/Zainoel Abidin General Hospital, Banda Aceh, 23111, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, 65117, Indonesia
