Jonny Karunia Fajar, Aditya Indra Mahendra, Fredo Tamara, Bagus Aulia Mahdi, Teuku Heriansyah, Mohammad Saifur Rohman
Objective: To determine the correlation between complete blood count and the risk of coronary heart disease (CHD). Material and Methods: All CHD patients treated in Aisyiyah Hospital during January 2011 to December 2017 were enrolled for the study. Information related to demographic, clinical, and complete blood count were extracted from medical record. Multiple logistic regression test was employed to evaluate the correlation between complete blood count and CHD incidence. In addition, a meta-analysis was also conducted to summarize findings from other regions. Results: A total of 516 CHD patients and 102 controls were included in our study. We found that elevated hemoglobin (OR 95%CI=4.92 [2.02-12.01], p=0.002), leukocyte (OR 95%CI=5.35 [3.17-9.03], p=0.001), hematocrit (OR 95%CI=2.31 [1.40-3.83], p=0.010), eosinophil (OR 95%CI= 2.78 [1.68-4.26], p=0.001), and monocyte (OR 95%CI=1.31 [0.80-2.16], p=0.023) were associated with the incidence of CHD. Furthermore, our meta-analysis revealed that elevated levels of leukocyte, eosinophil, and monocyte increased the risk of CHD approximately 3.57, 5.34, and 2.77 times, respectively. Conclusion: There is strong evidence that elevated levels of leukocyte, eosinophil, and monocyte are the risk factor for CHD. © 2019 by Türkiye Klinikleri.
Department of Medical Research Unit, Universitas Syiah Kuala Faculty of Medicine, Banda Aceh, Indonesia; Cardiology and Vascular Medicine, Universitas Syiah Kuala Faculty of Medicine, Banda Aceh, Indonesia; Departments of Magister of Biomedicine, Malang, Indonesia; Internal Medicine, Malang, Indonesia; Cardiology and Vascular Medicine, Universitas Brawijaya Faculty of Medicine, Malang, Indonesia; Clinic of Emergency Service, Aisyiyah Hospital, Malang, Indonesia
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