Erna Susanti, Retty Ratnawati, Aulanni'am Aulanni'am, Achmad Rudijanto
The efflux of cholesterol from macrophage to liver is known as reverse cholesterol transport (RCT). Impaired cholesterol efflux leads to cholesterol accumulation in macrophages. Therefore, how to increasing cholesterol efflux may be an effective strategy for atherosclerosis prevention. Key molecules that play a vital role in the efflux of cholesterol from macrophage are Adenosin Tri Phosphate (ATP)-binding casette transporters A1 and G. This study was undertaken to clarify the effect of Catechins on the expression of specific transporters such as ATP-binding cassette sub-family A member 1 (ABCA1), ATP-binding cassette sub-family G member 1 (ABCG1) from macrophage to liver, and scavenger receptor class B type I (SRB1). This research was done on Wistar rats induced atherogenic diets. SRB1 is one of the transporters to facilitate the delivery of cholesterol from the macrophage to the liver. The SRB1 pathway mediated the selective uptake of cholesteryl ester. Catechins significantly increased the mRNA expression of ABCA1 and ABCG1 in aorta as well as SRB1 of liver also increased. Thus, Catechins decreased the total cholesterol levels in aorta and serum. Catechins can be developed as a potential agent to increase ABCA1 to inhibit atherogenesis process. In conclusion, this study indicates that the potential anti-atherogenic properties of Catechins could be explained, at least in part, as being due to upregulated expression of ABCA1, ABCG1, and SRB1 through activation liver X receptor signaling pathway. © 2019 Erna Susanti et al.
Academy of Pharmacy and Food Analyst, Putra Indonesia Malang, Malang, Indonesia; Medical Faculty, Brawijaya University, Malang, Indonesia
