Djanggan Sargowo, Chamelia Rohadatul Aissy, Umi Kalsum, Faris Wahyu Nugroho, Putri Annisa Kamila, Dedy Irawan, Monika Sitio, Liemena Harold Adrian, Aditya Reza Pratama, Yusuf Arifin, Rizki Fadlan, Diah Ivana Sari, Evita Febriyanti Purwanto, Firyal Nadiah Rahmah, Merkuri Puspasari Sukatman, Nurul Aini Rahmawati, Rakhmawati Fahmiy
High free radical can induce oxidative stress, inflammation, and endothelial dysfunction in atherosclerosis. PsP of Ganoderma lucidum that proven as an effective anti inflammation, antioxidants, anti endothelial dysfunction and no toxicity in animal model in previous studies. This study aims to prove the role of PsP of Ganoderma lucidum as a potent protective vascular endothelial cell, anti inflammation, and antioxidant in STEMI and STEMI patients. This clinical trial study conducted to 45 patients according that diagnosed STEMI and NSTEMI, with pre- and post-test control group design. The parameters are IL-1, TNFα, MDA, SOD, NO concentration, CEC, and EPC counts. The patients were given PsP 750 mg/day in 3 divided dose for 90 days. Patients divided into two group randomized, one group were given PsP Ganoderma lucidum, and another group were given placebo. Independent T-test was performed for normally distributed data and Mann-Whitney test was performed for abnormally distributed data with significance level of p≤0.05. IL-1 (P=0,042) and TNF-α (P=0,003) level significantly decreased in PsP group patients. MDA level significantly decreased with P=0,000 in PsP group patients. SOD significantly increased with P=0,023 in PsP group patients, NO level significantly decreased with P=0,004 in PsP group patients, EPC count significantly increased with (P=0,000) in PsP group patients, CEC count significantly decreased in extract group patients with P= 0,032. Ganoderma lucidum polysaccharide peptides is a potent protective vascular endothelial cell, anti inflammation, antioxidant against pathogenesis of atherosclerosis in STEMI and NSTEMI patients. © 2019 Author(s).
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia; Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Laboratory of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, Indonesia
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