T.D. Widyaningsih, R. Fanani, A.I. Siska, E. Martati
Diabetes mellitus is a metabolic disorder disease caused by disorder of insulin secretion insulin action or both. Unlike the synthetic compounds, herbal of natural origin are safer and have less side effects. One of Indonesian herbal drink called "jamu" have many health effects, one of them is antidiabetic. Indonesian herbal drink "Mbah Jayus" is made by Zingiber officinale Rosc, Cymbopogun citrate, Nigella sativa, Cinnamomum chinense BL, and Amomum cardamomum Willd which has highly antioxidant. In this study, antioxidant property was evaluated using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging method (IC50), total phenolic content and total flavonoid content. The antidiabetic effect was conducted on Rattus norvegicus rats. Diabetes was induced with intraperitonial injection of alloxan monohydrate (150 mg/kg body weight). The result showed that Indonesian herbal drink "Mbah Jayus"can decrease significantly the blood glucose level (P<0.05) in treated rats. So, the antioxidants property of phenolic and flavonoid content might be responsible for the antidiabetic efficacy Indonesian herbal drink "Mbah Jayus". © 2019 Institute of Physics Publishing. All rights reserved.
Department of Agricultural Product Technology, Universitas Brawijaya, Malang, Indonesia; Graduate Stud. of Agricultural Product Technology, Universitas Brawijaya, Malang, Indonesia