Etik Sulistyowati, Dian Handayani, Setyawati Soeharto, Achmad Rudijanto
Aim: The study aimed to investigate the effect of serum mineral (Mg, Mn, and K) levels to obesity in rat model. Methods: A posttest-only control group design was used in this research. This research tested the feed type in Sprague-Dawley rats. A total 36 rats were divided into two groups (18 rats for normal feeding intervention (N) and 18 rats for high fat-high fructose modified standard diet (HFFD) feeding intervention). The treatments were conducted for 12 weeks. Energy, nutrients and mineral content of modified feed were measured. Moreover, calorie intake, weight, body length, abdominal circumference, lee index, and serum mineral content of rat samples were measured. Results: The results showed that weight gain was 11.94% higher in the HFFD group, and its caloric intake was significantly (p = 0.000) higher than N group. The abdominal ratios of the HFFD group were significantly higher than N group (p = 0.009) and the Mg, Mn and K serum levels of HFFD group were significantly lower than N group. There was a significant and negative correlation between increased BMI and abdominal circumference with decreased serum mineral levels. Conlusions: This study showed that HFFD causes a decrease in serum mineral (Mg, Mn, and K) levels which is associated with the incidence of obesity. Therefore, HFFD food consumption should be avoided. © 2019 Elsevier Ltd
Doctoral Programme, Faculty of Medicine, Universitas Brawijaya, Indonesia; Malang State Health Polytechnic, Ministry of Health, Malang, Indonesia; School of Nutrition, Faculty of Medicine, Universitas Brawijaya, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Indonesia; Department of Endocrinology, Faculty of Medicine, Universitas Brawijaya, Indonesia
