R. Adharyan Islamy, Reza Dwi Afandi, Diana Aisyah, Ayu Winna Ramadhani, Novalina Serdiati, Fitri Sil Valen, Hadiana Hadiana
Methomyl exposure induces genotoxic effects in aquatic organisms through oxidative damage to DNA. This study evaluated the antigenotoxic effects of leaf, fruit, and stem extracts of Sauropus androgynus in Oreochromis niloticus exposed to methomyl (4.015 ppm) for 96 h. Genotoxicity was assessed using micronucleus frequency and nuclear abnormalities in erythrocytes. Methomyl exposure increased both indicators compared to the control. Treatment with S. androgynus extracts reduced genotoxic damage, with efficacy varying among plant parts. Leaf extract produced values closest to the control, while fruit and stem extracts showed moderate and lower effects, respectively. The variation in response likely reflects differences in phytochemical composition among plant parts. These findings indicate that S. androgynus, particularly its leaves, can mitigate methomyl exposed genotoxicity in fish. © 2026, Egyptian Society for the Development of Fisheries and Human Health. All rights reserved.
Aquaculture (Kediri City Campus), Department of Fisheries and Marine Resources Management, Faculty of Fisheries and Marine Sciences, Brawijaya University, Jl. Pringgodani, East Java, Kediri City, 64111, Indonesia; PT Haida Agriculture Indonesia, Jl. Kraton Industri Raya No.4, Sawah, Pejangkungan, Kec. Kraton, Jawa Timur, Pasuruan, 67151, Indonesia; Aquatic Resources Management Study Program, Faculty of Animal Husbandry and Fisheries, Tadulako University, Central Sulawesi, Palu, 94118, Indonesia; Aquaculture Department, Agriculture Fisheries and Biology Faculty, Bangka Belitung University, Gang IV No.1, Balun Ijuk, Merawang District, Bangka Regency, Bangka Belitung Islands, 33172, Indonesia
