Muhammad Ilmawan, Avan Guntur Satriawan, Yeni Purnamasari, Bagus Aulia Mahdi, Fredo Tamara, Besut Daryanto, Atma Gunawan, Jonny Karunia Fajar
Objectives: In the last three decades, Glutathione S-Transferase P1 (GSTP1) 105IIe>Val had been extensively reported in the case of Bladder cancer (BC). However, conflicting results were observed among the studies. We aimed to perform a meta-analysis in effort to assess the association between GSTP1 105IIe>Val gene polymorphism and the risk of BC. Material and Methods: A meta-analysis was conducted between May and July 2019. Papers were searched in Pubmed, Embase, Cochrane, and Web of Science and information of interest was extracted. The correlation and effect estimation were analyzed using random or fixed effect model. Results: We collected 17 studies consisting of 4.236 cases and 5.085 controls. Our pooled calculation revealed that GSTP1 105IIe>Val gene polymorphism was not associated with the risk of BC (OR 95%CI=1.11 [0.97-1.26], p=0.1190). We also performed sub-group analyses in accordance with ethnicity and genotyping method. In ethnicity sub-group, we failed to clarify the correlation between GSTP1 105IIe>Val gene polymorphism and the risk of BC both in Asian and Caucasian sub-groups. While, in genotyping method sub-groups, either using polymerase chain reaction (PCR) or PCR-Restriction fragment length polymorphism (PCR-RFLP) had no significant association with the risk of BC. Conclusion: There is no association between GSTP1 105IIe>Val gene polymorphism and the risk of BC. © 2020 by Türkiye Klinikleri.
Universitas Brawijaya Faculty of Medicine, Malang, Indonesia; Universitas Brawijaya Faculty of Medicine, Department of Biomedicine, Malang, Indonesia; Universitas Airlangga, Faculty of Medicine, Department of Internal Medicine, Surabaya, Indonesia; Universitas Brawijaya, Faculty of Medicine, Department of Internal Medicine, Malang, Indonesia; Universitas Brawijaya, Faculty of Medicine, Department of Urology, Malang, Indonesia; Universitas Brawijaya, Faculty of Medicine, Department of Internal Medicine, Division of Nephrology and Hypertension, Malang, Indonesia
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