Didin Wahyu Agustina, Mulya Dwi Wahyuningsih, Sri Widyarti, Aris Soewondo, Hideo Tsuboi, Muhaimin Rifa’i
Introduction: Accumulation of polycyclic aromatic hydrocarbons (PAH) in the body commonly lead to degenerative disease such as cancer. This study aims to investigate the potential of Morinda citrifolia to maintain the immune system against toxic exposure. Material and Methods: This study used Five weeks old male Balb/C mice as animal model. The 7,12-Dimethylbenz(a)anthracene (DMBA) was administrated for six weeks following with 3 days cigarette smoke (CS) exposure then treated with noni juice (M. citrifolia) for two weeks. Experimental animals were divided into six groups. Normal control (N); DMBA+CS; Cisplatin; D1; D2; and D3. Profil of CD4+TNFα+, CD11b+IL6+, CD11b+IFNγ+, CD4+CD25+ IL10+, NK+IL6+ cells was analyzed by flow cytometry and data was analyzed with one-way ANOVA and Post Hoc Tukey HSD test with a significance of p-values < 0.05. Results: This study show that DMBA+CS induction increasing level of CD11b+IL6+, CD4+CD25+ IL-10+ and NK+ IL-6+ meanwhile decreasing CD4+TNFα+significantly (P<0.5) than Normal group. Noni juice in dose 90 mg/Kg BW decrease cytokine pro-inflammation (IL-6 and IFNγ) both in macrophage and NK cell profile significantly (P<0.05). Noni juice in 30 mg/Kg BW could improve the activation CD4+TNFα+ significantly (P<0.05). Noni juice also has efficacy to control T regulator activation to prevent tumor escape. Conclusion: These results suggest that noni juice has anti-cancer potencies by maintain homeostasis of immune system and could be immune herbal supplement. © 2020 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, 65145, Indonesia; Biosystems Research Center, LPPM University of Brawijaya, Malang, East Java, 65145, Indonesia; Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan
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