Abdul Rohim Tualeka, Ng Yee Guan, Syamsiar S. Russeng, Ahsan Ahsan, Indri H. Susilowati, Pudji Rahmawati, Khusnul Ain
In the shoes industry, benzene constitute as one of the source of chemical hazard especially used in the gluing section. This compound is metabolized by the liver, forming free radicals in the body which can ultimately reduce the concentration of glutathione and increased malondialdehyde causing DNA degeneration. The purpose of this study was to determine the relationship between benzene concentration, excess cancer risk (ECR), malondialdehyde, glutathione, and DNA degeneration among workers in shoes industry in Osowilangun, Surabaya. This is an observational study with a cross-sectional design. The number of research samples was 25 respondents. The average concentration of benzene in workers was above the threshold (10.31 ppm). There were 15 (60%) respondents with ECR >0.0001 who experienced DNA degeneration. There was no relationship between benzene concentration, malondialdehyde, glutathione, and DNA degeneration. However, there was a relationship between benzene ECR, malondialdehyde, glutathione, and DNA degeneration in the shoe industry workers in Osowilangun. © The Author(s) 2020.
Department of Occupational Health and Safety, Universitas Airlangga, Surabaya, East Java, Indonesia; Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Department of Occupational Health and Safety, Faculty of Public Health, Hassanudin University, Makassar, Indonesia; Faculty of Nurse, Brawijaya University, Malang, Indonesia; Public Health Faculty, University of Indonesia, Depok, Indonesia; Department of Development of Islamic Society, State Islamic University Sunan Ampel, Surabaya, Indonesia; Departement of Biology, Faculty of Sains and Technology, Airlangga University, Surabaya, East Java, Indonesia
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