Ach. Khumaidi, Feni Iranawati, Mohamad Fadjar, Maftuch, Masruri, Uun Yanuhar, Yuni Kilawati
Amphora sp. is a type of potential microalgae that has a considerably high content of lipid. The current experiment was carried out for the extraction and identification of Amphora sp. fatty acids, using n-hexane and petroleum ether as solvents, before studying their pharmacological properties, in silico. The results showed that petroleum ether gives a better yield of 3.58%, compared to n-Hexane (2.74%). The GCMS analysis of the sample extracted using petroleum ether shows six peaks corresponding to 6-Dodecanone; Methyl (E)-octadec-11-enoate; Methyl 15-methylhexadecanoate; 2,5-Dimethylcyclohexanol; 2,3-Dimethyl-undec-1-en-3-ol and 3,6,6-Trimethyl-2-norpinanol. Meanwhile, the sample extracted using n-hexane only shows two fatty acid compounds, i.e.: 2,3-Dimethyl-undec-1-en-3-ol and 3,6,6-Trimethyl-2-norpinanol. The absorption, distribution, metabolism, excretion and toxicity (ADMET) analysis showed that fatty acid compounds contained in Amphora sp. have potential as drug ingredients, based on the Lipinski's rule of five and on their pharmacokinetic properties. Biological activity based on the prediction of activity spectra for substances (PASS) shows that fatty acids contained in Amphora sp. have a considerably good activity as antivirals with a probability activity (Pa) value of 0.592-0.723, but also have several other activities, such as anti-inflammatory, antibacterial, antifungal, antineoplastic, and antioxidant. These results indicate that petroleum ether solvent is more effective than n-Hexane to extract fatty acids in Amphora sp., with a high potential as natural antiviral. © 2020, BIOFLUX SRL. All rights reserved.
Department of Aquaculture, Faculty of Science and Technology, University of Ibrahimy, Situbondo, Indonesia; Department of Marine Science, Faculty of Fisheries and Marine Science, University of Brawijaya, Malang, Indonesia; Department of Aquaculture, Faculty of Fisheries and Marine Sciences, University of Brawijaya, Malang, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Brawijaya, Malang, Indonesia; Department of Water Resources Management, Faculty of Fisheries and Marine Sciences, University of Brawijaya, Malang, Indonesia
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