Anita Febriana, Ery Olivianto, Husnul Khotimah
Tuberculosis (TB) caused by infection of Mycobacterium tuberculosis (MTb) has a complex immunological response that leading to a variety of lung pathology, as reflected on Chest X-ray (CXR) imaging. Tumor Necrosis Factor-a (TNF-α) and Interleukin-17 (IL-17) are also pro-inflammatory cytokines secreted as a response of MTb infection. Both have pleiotropic effects and excessive expressions are associated with lung damage. This study aims to determine the correlation between levels of TNF-α and IL-17 based on lung damage from CXR in paediatric TB. This is a cross-sectional study. The subjects include 38 TB patients divided into 3 groups; mild, moderate, and severe lung damage based on CXR, from January 2019 to July 2020. Plasma TNF-α and IL-17 levels measured using ELISA then compared to each group. There is a significant difference in TNF-α levels between mild vs moderate (p = 0.002), mild vs severe (p = 0.000), and moderate vs severe lung damage (p = 0.001). A positive correlation was also found between TNF-α levels and lung damage (p = 0.000, r = 0.796), whereas IL-17 shows no significant difference (p = 0.538). Increasing TNF-α level, but not IL-17, is associated with severity of lung damage in paediatric TB. © 2021 Author(s).
Department of Paediatrics, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Department of Biomedical Sciences, Faculty of Medicine, Brawijaya University, Malang, Indonesia
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