Putut Har Riyadi, Eko Susanto, Tri Winarni Agustini, Apri Dwi Anggo, Mochammad Fitri Atho’illah
Background: Spirulina platensis is a blue-green microalga known for its health benefits, including treating cardiovascular disease. However, research on the functional properties of S. platensis extracted via sonication remains limited. Aim: To investigate the efficacy of S. platensis hydromethanolic extract (SPE) on controlling blood pressure, renin– angiotensin–aldosterone system hormones, including renin, angiotensin-converting enzyme (ACE), and angiotensin II (Ang II), and pro-inflammatory cytokines in the spontaneously hypertensive rats (SHRs) model. Methods: Twenty-five male Wistar rats were divided into five groups (n = 5), and the 20 rats were administered deoxycorticosterone acetate-salt for 5 weeks to induce SHR and treated orally with SPE for 28 days. Blood pressure was evaluated three times: initial, middle, and final treatment. The rats were then sacrificed, and the blood serum was collected. The serum was then analyzed for renin, Ang II, ACE, tumor necrosis factor-α, and interleukin (IL)-6 using enzyme-linked immunosorbent assay. Malondialdehyde was determined based on a colorimetric assay. Results: Our results demonstrated that SPE could reduce hypertensive, inflammatory, and lipid peroxidation markers significantly (p < 0.05). Conclusion: Our finding suggested that SPE improves hypertension by maintaining inflammation and antioxidants. Spirulina platensis may be regarded as a potential nutraceutical supplement S. platensis may be regarded as a potential nutraceutical supplement from fishery product for managing hypertension and other diseases associated with inflammation disturbances. © 2026, Faculty of Veterinary Medicine, University of Tripoli. All rights reserved.
Department of Fishery Product Technology, Faculty of Fisheries and Marine Science, Diponegoro University, Semarang, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia
